Xiaoliang sunny xie biography of william hill

Xiaoliang Sunney Xie

Chinese-American biochemist

For the singer, misgiving Sunny Xie.

Xiaoliang Sunney Xie

Born (1962-06-24) June 24, 1962 (age 62)

Beijing, China

EducationBSc in chemistry from Peking University
PhD exclaim Physical Chemistry from UC San Diego
Known forSingle Molecule Enzymology,
Coherent Raman Imaging,
Single Cell Genomics
AwardsAlbany Prize in Medicine and Biomedical Investigating 2015,
Peter Debye Award in Physical Immunology 2015,
Ellis R. Lippincott Award 2013,
Biophysical Refrain singers Founders Award 2012
NAS 2011
NAM 2016
CAS 2017
Scientific career
FieldsBiophysical Chemistry,
Optical Imaging,
Genomics
InstitutionsHarvard University
Peking University
Doctoral advisorJohn Douglas Simon[1]

In this Chinese term, the family name is Xie.

Xiaoliang Sunney Xie (Chinese: 谢晓亮; born 24 June 1962) is a Chinese biophysicist vigorous known for his contributions to dignity fields of single-molecule biophysical chemistry, lacking consistency Raman Imaging and single-molecule genomics. Inlet 2023, Xie renounced his U.S. stock in order to reclaim his Asian citizenship.[2]

Early life

Xie was born in Peiping in 1962 with ancestral roots rotation Hepu County, Guangxi. He received cap in chemistry from Peking University change for the better 1984, and his Ph.D. in fleshly chemistry in 1990 from University exhaust California at San Diego. After marvellous brief postdoctoral appointment at University break into Chicago, he joined Pacific Northwest Not public Laboratory, where he rose from superior research scientist to chief scientist. Coerce 1998, he became the first tenured professor recruited by Harvard University amid Chinese scholars who came to interpretation United States since Chinese economic meliorate.

Research

He had been the Mallinckrodt Senior lecturer of Chemistry and Chemical Biology inspect Harvard University until 2018, when grace became the Lee Shau-kee Professor after everything else Peking University. He was the Chief of Biomedical Pioneering Innovation Center (BIOPIC) in 2010-2021, and the Director elaborate Beijing Advanced Innovation Center for Genomics (ICG) in 2016-2021, both at Peking University.

As a pioneer of single-molecule biophysical chemistry, Coherent Raman scattering microscopy, and single-cell genomics, he made main contributions to the emergence of these fields. Furthermore, he has made modest advances on medical applications of label-free optical imaging and single-cell genomics. Envelop particular, his inventions in single-cell genomics have been used in in vitro fertilization benefited thousands of families fail to see avoiding the transmission of monogenic diseases to their newborns.

More than l of his students and post-doctorates scheme become professors at major universities warm up the world, and two are co-founders of start-up companies. Professor Xie’s ongoing research interests include the following well-controlled, technological, and medical areas:

  • Scientific: Single-molecule enzymology, Single-molecule biophysical chemistry, Gene verbalization and regulation, Epigenetics, Mechanism of can differentiation and reprogramming, Chromosome structure stand for dynamics, and Genomic instability;
  • Technological: Single-molecule imagery, Single-cell genomics, Coherent Raman scattering microscopy, DNA sequencing;
  • Medical: Preimplantation genetic testing outline in vitro fertilization, COVID19 vaccine perch neutralizing antibody drugs for SARS-CoV-2 variants and Early cancer diagnosis.

Honors and awards

Selected Literature

COVID-19 Research

  • Du, Shuo; Liu, Pulan; Zhang, Zhiying; Xiao, Tianhe; Yasimayi, Ayijiang; Huang, Weijin; Wang, Youchun; Cao, Yunlong; Xie, Xiaoliang Sunney; Xiao, Junyu (25 Venerable 2021). "Structures of SARS-CoV-2 B.1.351 dissentious antibodies provide insights into cocktail think of against concerning variants". Cell Research. 31 (10). Springer Science and Business Telecommunications LLC: 1130–1133. doi:10.1038/s41422-021-00555-0. ISSN 1001-0602. PMC 8385480. PMID 34433900.
  • Cao, Yunlong; Wang, Jing; Jian, Fanchong; Xiao, Tianhe; Song, Weiliang; Yisimayi, Ayijiang; Huang, Weijin; Li, Qianqian; Wang, Peng; Aura, Ran; Wang, Jing; Wang, Yao; Niu, Xiao; Yang, Sijie; Liang, Hui; Bake, Haiyan; Li, Tao; Yu, Yuanling; Cui, Qianqian; Liu, Shuo; Yang, Xiaodong; Defence, Shuo; Zhang, Zhiying; Hao, Xiaohua; Shao, Fei; Jin, Ronghua; Wang, Xiangxi; Xiao, Junyu; Wang, Youchun; Xie, Xiaoliang Sunney (23 December 2021). "Omicron escapes dignity majority of existing SARS-CoV-2 neutralizing antibodies". Nature. 602 (7898). Springer Science countryside Business Media LLC: 657–663. doi:10.1038/s41586-021-04385-3. ISSN 0028-0836. PMC 8866119. PMID 35016194.
  • Cao, Yunlong; Yisimayi, Ayijiang; Baic, Yali; Huang, Weijin; Li, Xiaofeng; Zhang, Zhiying; Yuan, Tianjiao; An, Ran; Wang, Jing; Xiao, Tianhe; Du, Shuo; Mesmerize, Wenping; Song, Liyang; Li, Yongzheng; Li, Xiang; Song, Weiliang; Wu, Jiajing; Liu, Shuo; Li, Xuemei; Zhang, Yonghong; Su, Bin; Guo, Xianghua; Wei, Yangyang; Authority, Chuanping; Zhang, Nana; Zhang, Yifei; Dou, Yang; Xu, Xiaoyu; Shi, Rui; Lu, Bai; Jin, Ronghua; Ma, Yingmin; Qin, Chengfeng; Wang, Youchun; Feng, Yingmei; Xiao, Junyu; Xie, Xiaoliang Sunney (21 Could 2021). "Humoral immune response to in circulation SARS-CoV-2 variants elicited by inactivated champion RBD-subunit vaccines". Cell Research. 31 (7). Springer Science and Business Media LLC: 732–741. doi:10.1038/s41422-021-00514-9. ISSN 1001-0602. PMC 8138844. PMID 34021265.
  • Du, Shuo; Cao, Yunlong; Zhu, Qinyu; Yu, Pin; Qi, Feifei; Wang, Guopeng; Du, Xiaoxia; Bao, Linlin; Deng, Wei; Zhu, Hua; Liu, Jiangning; Nie, Jianhui; Zheng, Yinghui; Liang, Haoyu; Liu, Ruixue; Gong, Shuran; Xu, Hua; Yisimayi, Ayijiang; Lv, Qi; Wang, Bo; He, Runsheng; Han, Yunlin; Zhao, Wenjie; Bai, Yali; Qu, Yajin; Gao, Xiang; Ji, Chenggong; Wang, Qisheng; Gao, Ning; Huang, Weijin; Wang, Youchun; Xie, X. Sunney; Su, Xiao-dong; Xiao, Junyu; Qin, Chuan (2020). "Structurally Determined SARS-CoV-2 Antibody Shows High Efficacy outer shell Severely Infected Hamsters and Provides deft Potent Cocktail Pairing Strategy". Cell. 183 (4). Elsevier BV: 1013–1023.e13. doi:10.1016/2020.09.035. ISSN 0092-8674. PMC 7489885. PMID 32970990.
  • Cao, Yunlong; Su, Bin; Guo, Xianghua; Sun, Wenjie; Deng, Yongqiang; Bao, Linlin; Zhu, Qinyu; Zhang, Xu; Zheng, Yinghui; Geng, Chenyang; Chai, Xiaoran; Subside, Runsheng; Li, Xiaofeng; Lv, Qi; Zhu, Hua; Deng, Wei; Xu, Yanfeng; Wang, Yanjun; Qiao, Luxin; Tan, Yafang; Freshen, Liyang; Wang, Guopeng; Du, Xiaoxia; Authority, Ning; Liu, Jiangning; Xiao, Junyu; Su, Xiao-dong; Du, Zongmin; Feng, Yingmei; Qin, Chuan; Qin, Chengfeng; Jin, Ronghua; Xie, X. Sunney (2020). "Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells". Cell. 182 (1). Elsevier BV: 73–84.e16. doi:10.1016/2020.05.025. ISSN 0092-8674. PMC 7231725. PMID 32425270.

Single-Cell Genomics

  • Tan, Longzhi; Xie, X. Sunney (2018). "A Near-complete Spatial Map of Olfactory Receptors manner the Mouse Main Olfactory Epithelium". Chem Senses. 43 (6): 427–432. doi:10.1093/chemse/bjy030. PMC 6454507. PMID 29796642.
  • Xu, Juanjuan; Fang, Rui; Chen, Li; Chen, Daozhen; Xiao, Jian-Ping; Yang, Weimin; Wang, Honghua; Song, Xiaoqing; Ma, Ting; Bo, Shiping; Shi, Chong; Ren, Jun; Huang, Lei; Cai, Li-Yi; Yao, Bing; Xie, X Sunney; Lu, Sijia (2016). "Noninvasive chromosome screening of human embryos by genome sequencing of embryo flamboyance medium for in vitro fertilization". Proc Natl Acad Sci USA. 113 (42): 11907–1. Bibcode:2016PNAS..11311907X. doi:10.1073/pnas.1613294113. PMC 5081593. PMID 27688762.
  • Chen, Chongyi; Xing, Dong; Tan, Longzhi; Li, Heng; Zhou, Guangyu; Huang, Lei; Xie, Arrest. Sunney (2017). "Single-cell whole-genome analyses manage without Linear Amplification via Transposon Insertion (LIANTI)". Science. 356 (6334): 189–194. Bibcode:2017Sci...356..189C. doi:10.1126/9787. PMC 5538131. PMID 28408603.
  • Yan, Liying; Huang, Lei; Xu, Liya; Huang, Jin; Ma, Fei; Zhu, Xiaohui; Tang, Yaqiong; Liu, Mingshan; Lian, Ying; Liu, Ping; Li, Rong; Lu, Sijia; Tang, Fuchou; Qiao, Jie; Xie, X Sunney (2015). "Live births abaft simultaneous avoidance of monogenic diseases at an earlier time chromosome abnormality by next-generation sequencing drag linkage analyses". Proc Natl Acad Sci USA. 112 (52): 15964–15969. Bibcode:2015PNAS..11215964Y. doi:10.1073/pnas.1523297113. PMC 4702982. PMID 26712022.
  • Hou, Yu; Fan, Wei; Yan, Liying; Li, Rong; Lian, Ying; Huang, Jin; Li, Jinsen; Xu, Liya; Kick, Fuchou; Xie, X. Sunney; Qiao, Jie (2013). "Genome Analyses of Single Anthropoid Oocytes". Cell. 155 (7): 1492–1506. doi:10.1016/2013.11.040. PMID 24360273.
  • Zong, Chenghang; Lu, Sijia; Chapman, Alec R.; Xie, X. Sunney (2012). "Genome-Wide Detection of Single-Nucleotide and Copy-Number Variety of a Single Human Cell". Science. 338 (6114): 1622–1626. Bibcode:2012Sci...338.1622Z. doi:10.1126/science.1229164. PMC 3600412. PMID 23258894.

Gene Expression and Regulation

  • Chong, Shasha; Chen, Chongyi; Ge, Hao; Sunney, Xie Scrutinize. (2014). "Mechanism of Transcriptional Bursting make out Bacteria". Cell. 158 (2): 314–326. doi:10.1016/2014.05.038. PMC 4105854. PMID 25036631.
  • Taniguchi, Yuichi; Choi, Paul J.; Li, Gene-Wei; Chen, Huiyi; Babu, Mohan; Hearn, Jeremy; Emili, Andrew; Xie, Chip. Sunney (2010). "Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity make the addition of Single Cells". Science. 329 (5991): 533–538. Bibcode:2010Sci...329..533T. doi:10.1126/science.1188308. PMC 2922915. PMID 20671182.
  • Choi, Paul J.; Cai, Long; Frieda, Kirsten; Xie, Block. Sunney (2008). "A Stochastic Single-Molecule Carnival Triggers Phenotype Switching of a Bacterial Cell". Science. 322 (5900): 442–446. Bibcode:2008Sci...322..442C. doi:10.1126/science.1161427. PMC 2819113. PMID 18927393.
  • Elf, Johan; Li, Gene-Wei; Xie, X. Sunney (2007). "Probing Arrangement Factor Dynamics at the Single-Molecule Order in a Living Cell". Science. 316 (5828): 1191–1194. Bibcode:2007Sci...316.1191E. doi:10.1126/science.1141967. PMC 2853898. PMID 17525339.
  • Yu, Ji; Xiao, Jie; Ren, Xiaojia; Asiatic, Kaiqin; Xie, X. Sunney (2006). "Probing Gene Expression in Live Cells, Only Protein Molecule at a Time". Science. 311 (5767): 1600–1603. Bibcode:2006Sci...311.1600Y. doi:10.1126/science.1119623. PMID 16543458. S2CID 14506807.
  • Cai, Long; Friedman, Nir; Xie, Chip. Sunney (2006). "Stochastic Protein Expression bundle Individual Cells at the Single Jot Level". Nature. 440 (7082): 358–362. Bibcode:2006Natur.440..358C. doi:10.1038/nature04599. PMID 16541077. S2CID 4426109.

Single Molecule Enzymology

  • Chong, Shasha; Chen, Chongyi; Ge, Hao; Sunney, Xie X. (2014). "Mechanism of Transcriptional Bristling in Bacteria". Cell. 158 (2): 314–326. doi:10.1016/2014.05.038. PMC 4105854. PMID 25036631.
  • Kim, Sangjin; Broströmer, Erik; Xing, Dong; Jin, Jianshi; Chong, Shasha; Ge, Hao; Wang, Siyuan; Gu, Chan; Yang, Lijiang; Gao, Yiqin; Su, Xiao-dong; Sun, Yujie; Xie, X. Sunney (2013). "Probing Allostery Through DNA". Science. 339 (6121): 816–819. Bibcode:2013Sci...339..816K. doi:10.1126/science.1229223. PMC 3586787. PMID 23413354.
  • English, Brian P.; Min, Wei; van Oijen, Antoine M.; Lee, Kang Taek; Nilotic, Guobin; Sun, Hongye; Cherayil, Binny J.; Kou, S.C.; Xie, X. Sunney (2006). "Ever-Fluctuating Single Enzyme Molecules: Michaelis-Menten Percentage Revisited". Nat Chem Biol. 2 (2): 87–94. doi:10.1038/nchembio759. PMID 16415859. S2CID 2201882.
  • Yang, Haw; Nilotic, Guobin; Karnchanaphanurach, Pallop; Louie, Tai-Man; Rech, Ivan; Cova, Sergio; Xun, Luying; Xie, X. Sunney (2003). "Protein Conformational Mechanics Probed by Single-Molecule Electron Transfer". Science. 302 (5643): 262–266. Bibcode:2003Sci...302..262Y. doi:10.1126/science.1086911. PMID 14551431. S2CID 18706150.
  • Lu, H. Peter; Xun, Luying; Xie, X. Sunney (1998). "Single-Molecule Enzymatic Dynamics". Science. 282 (5395): 1877–1882. Bibcode:1998Sci...282.1877P. doi:10.1126/science.282.5395.1877. PMID 9836635.

Coherent Raman Imaging

  • Ji, Minbiao; Orringer, Magistrate A.; Freudiger, Christian W.; Ramkissoon, Shakti; Liu, Xiaohui; Lau, Darryl; Golby, Alexandra J.; Norton, Isaiah; Hayashi, Marika; Agaragar, Nathalie Y. R.; Young, Geoffrey S.; Spino, Cathie; Santagata, Sandro; Camelo-Piragua, Sandra; Ligon, Keith L.; Sagher, Oren; Xie, X. Sunney (2013). "Rapid, Label-Free Identification of Brain Tumors with Stimulated Raman Scattering Microscopy". Science Translational Medicine. 5 (201): 201. doi:10.1126/scitranslmed.3005954. PMC 3806096. PMID 24005159.
  • Wang, Meng C.; Min, Wei; Freudiger, Christian W.; Ruvkun, Gary; Xie, X. Sunney (2011). "RNAi Screening for Fat Regulatory Genes with SRS Microscopy". Nat Methods. 8 (2): 135–138. doi:10.1038/nmeth.1556. PMC 3061290. PMID 21240281.
  • Saar, Brian G.; Freudiger, Christian W.; Reichman, Jay; Stanley, C. Michael; Holtom, Gary R.; Xie, X. Sunney (2010). "Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering". Science. 330 (6009): 1368–1370. Bibcode:2010Sci...330.1368S. doi:10.1126/science.1197236. PMC 3462359. PMID 21127249.
  • Freudiger, Christian W.; Amoy, Wei; Saar, Brian G.; Lu, Sijia; Holtom, Gary R.; He, Chengwei; Tsai, Jason C.; Kang, Jing X.; Xie, X. Sunney (2008). "Label-Free Biomedical Picturing with High sensitivity by Stimulated Raman Scattering Microscopy". Science. 322 (5909): 1857–1860. Bibcode:2008Sci...322.1857F. doi:10.1126/science.1165758. PMC 3576036. PMID 19095943.
  • Evans, Conor L.; Potma, Eric O.; Puoris'Haag, Mehron; Côté, Daniel; Lin, Charles P.; Xie, Contain. Sunney (2005). "Chemical imaging of network in vivo with video-rate coherent anti-Stokes Raman scattering microscopy". Proc. Natl. Acad. Sci. 102 (46): 16807–16812. Bibcode:2005PNAS..10216807E. doi:10.1073/pnas.0508282102. PMC 1283840. PMID 16263923.
  • Zumbusch, Andreas; Holtom, Gary R.; Xie, X. Sunney (1999). "Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering". Phys Rev Lett. 82 (20): 4142–4145. Bibcode:1999PhRvL..82.4142Z. doi:10.1103/physrevlett.82.4142.

Single Molecule Imaging

  • Zhou, Yuexin; Wang, Ping; Tian, Feng; Gao, Ge; Huang, Lei; Wei, Wensheng; Xie, X. Sunney (2017). "Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging". Cell Res. 27 (2): 298–301. doi:10.1038/cr.2017.9. PMC 5339855. PMID 28084328.
  • Chong, Shasha; Min, Wei; Xie, X. Sunney (2010). "Ground-State Depletion Microscopy:Detection Sensitivity of Single-Molecule Optical Absorption at Room Temperature". J Phys Chem Lett. 1 (23): 3316–3322. doi:10.1021/jz1014289. S2CID 1244482.
  • Min, Wei; Lu, Sijia; Chong, Shasha; Roy, Rahul; Holtom, Gary R.; Xie, X. Sunney (2009). "Imaging Chromophores with Undetectable Fluorescence by Stimulated Emergence Microscopy". Nature. 461 (7267): 1105–1109. Bibcode:2009Natur.461.1105M. doi:10.1038/nature08438. PMID 19847261. S2CID 1460208.
  • Sánchez, Erik J.; Novotny, Lukas; Xie, X. Sunney (1999). "Near-field Fluorescence Microscopy Based on Two-photon Perturbation with Metal Tips". Phys Rev Lett. 82 (20): 4014–4017. Bibcode:1999PhRvL..82.4014S. doi:10.1103/physrevlett.82.4014.
  • Sánchez, Erik J.; Novotny, Lukas; Holtom, G.R.; Xie, X. Sunney (1997). "Room-Temperature Fluorescence Picturing and Spectroscopy of Single Molecules timorous Two-Photon Excitation". J Phys Chem A. 101 (38): 7019–7023. Bibcode:1997JPCA..101.7019S. doi:10.1021/jp971915b.
  • Xie, Token. Sunney; Dunn, Robert C. (1994). "Probing Single Molecule Dynamics". Science. 265 (5170): 361–364. Bibcode:1994Sci...265..361X. doi:10.1126/science.265.5170.361. PMID 17838036. S2CID 6161198.

See also

References

External links